This is the Department of Applied Pathology, Graduate School of Medicine, The University of Tokyo.
Publications
最近の業績をご紹介します
Tissue clearing method in visualization of cancer progression and metastasis
Kei Takahashi-Yamashiro, et al
Despite advances in imaging modalities, detection of cancer metastasis remains limited by spatial resolution. Tissue-clearing technology, originally developed in neuroscience, enables single-cell resolution imaging and 3D visualization of metastatic foci across whole mouse organs. This review outlines the principles of tissue clearing, its current applications in cancer research, and its potential and limitations.
Receptor-activated transcription factors and beyond: multiple modes of Smad2/3-dependent transmission of TGF-β signaling
Keiji Miyazawa, et al
TGF-β signaling is mediated by receptor-activated Smad proteins, which function as transcription factors downstream of ubiquitously expressed TGF-β family receptors. In addition to transcriptional regulation, Smads control multiple post-transcriptional processes and other signaling pathways, including mitochondrial regulation. This review summarizes these diverse functions and highlights differences between Smad2 and Smad3.
SMAD1/5-mediated recruitment of the histone demethylase KDM1A controls cell fate programs in embryonic stem cells
Masato Morikawa, et al
BMP signaling via SMAD1/5 plays roles in mESCs, but its function remains unclear. Here, we show that SMAD1/5 recruit KDM1A/LSD1 to specific genomic regions to remove enhancer-associated H3K4me1/2 marks, thereby repressing cell type–specific gene expression. These findings identify a SMAD1/5–KDM1A axis as a key mechanism of transcriptional repression in mESCs.
